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KMID : 0882420070730060603
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Korean Journal of Medicine
2007 Volume.73 No. 6 p.603 ~ p.610
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The clinical effects of body mass index in patients with acute myocardial infarction after percutaneous coronary intervention
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Jeong Seon-Young
Rhee Jung-Ae
Jeong Myung-Ho
Hwang Seon-Ho
Yoon Nam-Sik
Hong Seo-Na
Lee Sang-Rok
Kim Kye-Hun
Moon Jae-Youn
Hong Young-Joon
Park Hyung-Wook
Kim Ju-Han
Ahn Young-Keun
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
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Abstract
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Background : Obesity is one of the major risk factors for coronary artery disease. However, the long-term clinical effects of obesity after percutaneus coronary intervention (PCI) in Korean patients with acute myocardial infarction (AMI) have not been sufficiently evaluated.
Methods : A total of 309 patients (mean age 60.5±11.3 years, M:F=243:66) that underwent PCI with a diagnosis of AMI between February 2002 and June 2006. Thepatients were divided into two groups according to the body mass index (BMI): group I (n=194; BMI <25 kg/m2; mean age 61.7±11.1 years, M:F=151:43) and group II (n=115; BMI≥25 kg/m2, mean age 58.2±11.3 years, M:F=92:23). Clinical characteristics and risk factors, and major adverse cardiac events during a six-month follow-up were compared between patients in the two gropus.
Results : The mean age of group I patients was older than that of group II patients (61.7±11.1 years vs. 58.6±11.5 years, p=0.017). The prevalence of hypertension was higher in group II patients (75/194, 38.7% vs.59/115, 51.3%, p=0.033) and hyperlipidemia was more prevalent in group II patients (75/194, 38.7% vs. 60/115, 52.2%, p=0.024). The levels of total cholesterol (184.3±39.9 mg/dL vs. 201.4±42.6 mg/dL, p=0.001), triglycerides (121.2±61.6 mg/dL vs. 147.1±96.2 mg/dL, p=0.005), low-density lipoprotein-cholesterol (120.3±35.1 mg/dL vs. 134.1±37.8 mg/dL, p=0.002) were lower in group I patients than in group II patients. The restenosis rate on a follow-up coronary angiogram was higher in group II patients (18/69, 26.1%) than in group I patients (14/109, 12.8%, p=0.025).
Conclusions : Obesity is associated with hyperlipidemia and hypertension in patients with AMI. The restenosis rate after PCI was higher in obese AMI patients.
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KEYWORD
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Myocardial infarction, Obesity, Prognosis
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